27. Gloria E. O. Borgstahl William B. O’Dell Martin Egli Jan F. Kern Andrey Kovalevsky Jiao Y. Y. LinDean Myles Mark A. Wilson Wen ZhangPetrus Zwart, and  Leighton Coates, EWALD: A macromolecular diffractometer for the second target station.”, Rev. Sci. Instrum., 2022, 93, 064103.

26. Yuliya Dantsu, Ying Zhang and Wen Zhang*, "Advances in Therapeutic L-Nucleosides and L-Nucleic Acids with Unusual Handedness." Genes, 2022, 13(1), 46.


25. Yuliya Dantsu, Ying Zhang and Wen Zhang*, “Synthesis of 2′-Deoxy-2′-fluoro-L-cytidine and Fluorinated L-Nucleic Acids for Structural Studies”, ChemistrySelect2021, 6(39), 10597–10600.

24. Yuliya Dantsu, Ying Zhang and Wen Zhang*, “Synthesis and structural characterization of 2'-deoxy-2'-fluoro-L-uridine nucleic acids”, Organic Letters2021, 23(13), 5007–5011.


23. Wen Zhang, Seohyun Chris Kim, Chun Pong Tam, Victor S. Lelyveld, Saikat Bala, John C. Chaput and Jack W. Szostak*, Nucleic Acids Research, 2021, 49(2), 646-656.


22. Victor S. Lelyveld, Wen Zhang and Jack W. Szostak*, Proceedings of the National Academy of Sciences of the United States of America2020, 117(13), 7276-7283.

21. Seohyun Chris Kim, Lijun Zhou, Wen Zhang, Derek K. O'Flaherty, Valeria Rondo-Brovetto and Jack W. Szostak*, Journal of American Chemical Society2020, 142(5), 2317-2326.

20. Tom H. Wright, Constantin Giurgiu, Wen Zhang, Aleksandar Radakovic, Derek K. O’Flaherty, Lijun Zhou and Jack W. Szostak*, Journal of American Chemical Society2019, 141(45), 18104-18112.

19. Travis Walton, Wen Zhang, , Li Li, Chun Pong Tam and Jack W. Szostak*, "The Mechanism of Nonenzymatic Template Copying with Imidazole‐Activated Nucleotides", Angewandte Chemie International Edition​, 2019, 131, 2-10.

18. Wen Zhang, Travis Walton, Li Li and Jack W. Szostak*, “Crystallographic observation of nonenzymatic RNA primer extension”, eLife, 2018, 7:e36422. DOI: https://doi.org/10.7554/ eLife.36422. (Highlighted by Nature Chemical Biology News, 2018, 14, 745.)

17. Wen Zhang, Chun Pong Tam, Lijun Zhou, Seung Soo Oh, Jiawei Wang, and Jack W. Szostak*, “A structural rationale for the enhanced catalysis of nonenzymatic RNA primer extension by a downstream oligonucleotide”, Journal of American Chemical Society, 2018, 140(8), 2829-2840.

16.Chun Pong Tam, Lijun Zhou, Albert C. Fahrenbach, Wen Zhang and Jack W. Szostak*, “Synthesis of a nonhydrolyzable nucleotide phosphoroimidazolide analogue that catalyzes nonenzymatic RNA primer extension”, Journal of American Chemical Society, 2018, 140(2), 783-792.

15. Wen Zhang, Chun Pong Tam, Travis Walton, Gabriel Birrane, and Jack W. Szostak*, “Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex”, Proceedings of the National Academy of Sciences of the United States of America2017, 114(29), 7659-7664.

14. Wen Zhang, Chun Pong Tam, Jiawei Wang, and Jack W. Szostak*. “Unusual base-pairing interactions in monomer–template complexes”, ACS Central Science2016, 2(12), 916-926. (Featured by ScienceDaily News and Phys News)

13. Wen Zhang, Jack W. Szostak, and Zhen Huang*, “Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom”, Frontiers of Chemical Science and Engineering2016, 10(2), 196-202.

12. Enver C. Izgu, Albert C. Fahrenbach, Na Zhang, Li Li, Wen Zhang, Aaron T. Larsen, J. Craig Blain, and Jack W. Szostak*, “Uncovering the thermodynamics of monomer binding for RNA replication”, Journal of American Chemical Society2015, 137(19), 6373–6382.

11. Liqin Zhang, Zunyi Yang, Kwame Sefah, Kevin M. Bradley, Shuichi Hoshika, Myong-Jung Kim, Hyo-Joong Kim, Guizhi Zhu, Elizabeth Jiménez, Sena Cansiz, I-Ting Teng, Carole Champanhac, Christopher McLendon, Chen Liu, Wen Zhang, Dietlind L. Gerloff, Zhen Huang, Weihong Tan, and Steven A. Benner*, “Evolution of functional six-nucleotide DNA”, Journal of American Chemical Society2015, 137(21), 6734–6737. (Featured by Phys News and Genengnews News)

10. Wen Zhang, Abdalla E. A. Hassan, Zhen Huang*, “Synthesis of novel di-Se-containing thymidine and Se-DNAs for structure and function studies”, Science China Chemistry2013, 56(3), 273-278.

9. Jia Sheng, Wen Zhang, Abdalla E. A. Hassan, Jianhua Gan, Alexei Soares, Song Geng, Yi Ren, Zhen Huang*, "Hydrogen bond formation between the naturally modified nucleobase and phosphate backbone", Nucleic Acids Research2012, 40(16), 8111-8118. 

8. Wen Zhang, Jia Sheng, Abdalla E. A. Hassan and Zhen Huang*, “Synthesis of novel 2’-deoxy-5-(methylselenyl)cytidine and Se-DNAs for structure and function studies”, Chemistry-An Asian Journal2012, 7(3), 476–479. 

7. Wen Zhang and Zhen Huang*, “Synthesis of the 5’-Se-Thymidine phosphoramidite and convenient labeling of oligonucleotides”, Organic Letters, 2011, 13(8), 2000-2003. 

6. Jia Sheng, Abdalla E. A. Hassan, Wen Zhang, Jianfeng Zhou, Bingqian Xu, Alexei S. Soares and Zhen Huang*, “Synthesis, structure and imaging of oligodeoxyribonucleotides with tellurium-nucleobase derivatization”, Nucleic Acids Research2011, 39(9), 3962-3971. 

5. Wen Zhang, Jia Sheng and Zhen Huang*, book chapter: “Structures and functions of nucleic acids modified with Sulfur, selenium and tellurium and complexed with small molecules”, Medicinal Chemistry of Nucleic Acids (John Wiley & Sons, Inc.), 2011, 101-141. 

4. Wen Zhang and Zhen Huang*, “Synthesis of a 2-Selenothymidine phosphoramidite and its incorporation into oligodeoxyribonucleotides”, Current Protocols in Nucleic Acid Chemistry (John Wiley & Sons, Inc.), 2010, 1.23.1-1.23.13. 

3. Abdalla E. A. Hassan, Jia Sheng, Wen Zhang, and Zhen Huang*, “High fidelity of base paring by 2-selenothymidine in DNA”, Journal of American Chemical Society2010, 132(7), 2120–2121.

2. Abdalla E. A. Hassan, Jia Sheng, Jiansheng Jiang, Wen Zhang, and Zhen Huang*, “Synthesis and crystallographic analysis of 5-Se-Thymidine DNAs”, Organic Letters2009, 11(12), 2503-2506. (Featured by C&EN News, vol. 87, no. 23, p. 51, June 8, 2009)

1. Daijuan Wang*,Jin-liang Niu,Wen-bo Zhang,Xiao-juan Jian,Wen Zhang, “Research progress and current status of hemoglobin-based blood substitutes”, Chinese Journal of Biochemical Pharmaceutic, 2005, 26, 379-382.