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28. Yuliya Dantsu and Wen Zhang*, “Derivatization of Mirror-image L-Nucleic Acids with 2'-OMe Modification for Thermal and Structural Stabilization”, ChemBioChem, 2023, e202200764.


27. Gloria E. O. Borgstahl William B. O’Dell Martin Egli Jan F. Kern Andrey Kovalevsky Jiao Y. Y. LinDean Myles Mark A. Wilson Wen ZhangPetrus Zwart, and  Leighton Coates, EWALD: A macromolecular diffractometer for the second target station.”, Rev. Sci. Instrum., 2022, 93, 064103.

26. Yuliya Dantsu, Ying Zhang and Wen Zhang*, "Advances in Therapeutic L-Nucleosides and L-Nucleic Acids with Unusual Handedness." Genes, 2022, 13(1), 46.


25. Yuliya Dantsu, Ying Zhang and Wen Zhang*, “Synthesis of 2′-Deoxy-2′-fluoro-L-cytidine and Fluorinated L-Nucleic Acids for Structural Studies”, ChemistrySelect2021, 6(39), 10597–10600.

24. Yuliya Dantsu, Ying Zhang and Wen Zhang*, “Synthesis and structural characterization of 2'-deoxy-2'-fluoro-L-uridine nucleic acids”, Organic Letters2021, 23(13), 5007–5011.


23. Wen Zhang, Seohyun Chris Kim, Chun Pong Tam, Victor S. Lelyveld, Saikat Bala, John C. Chaput and Jack W. Szostak*, Nucleic Acids Research, 2021, 49(2), 646-656.


22. Victor S. Lelyveld, Wen Zhang and Jack W. Szostak*, Proceedings of the National Academy of Sciences of the United States of America2020, 117(13), 7276-7283.

21. Seohyun Chris Kim, Lijun Zhou, Wen Zhang, Derek K. O'Flaherty, Valeria Rondo-Brovetto and Jack W. Szostak*, Journal of American Chemical Society2020, 142(5), 2317-2326.

20. Tom H. Wright, Constantin Giurgiu, Wen Zhang, Aleksandar Radakovic, Derek K. O’Flaherty, Lijun Zhou and Jack W. Szostak*, Journal of American Chemical Society2019, 141(45), 18104-18112.

19. Travis Walton, Wen Zhang, , Li Li, Chun Pong Tam and Jack W. Szostak*, "The Mechanism of Nonenzymatic Template Copying with Imidazole‐Activated Nucleotides", Angewandte Chemie International Edition​, 2019, 131, 2-10.

18. Wen Zhang, Travis Walton, Li Li and Jack W. Szostak*, “Crystallographic observation of nonenzymatic RNA primer extension”, eLife, 2018, 7:e36422. DOI: eLife.36422. (Highlighted by Nature Chemical Biology News, 2018, 14, 745.)

17. Wen Zhang, Chun Pong Tam, Lijun Zhou, Seung Soo Oh, Jiawei Wang, and Jack W. Szostak*, “A structural rationale for the enhanced catalysis of nonenzymatic RNA primer extension by a downstream oligonucleotide”, Journal of American Chemical Society, 2018, 140(8), 2829-2840.

16.Chun Pong Tam, Lijun Zhou, Albert C. Fahrenbach, Wen Zhang and Jack W. Szostak*, “Synthesis of a nonhydrolyzable nucleotide phosphoroimidazolide analogue that catalyzes nonenzymatic RNA primer extension”, Journal of American Chemical Society, 2018, 140(2), 783-792.

15. Wen Zhang, Chun Pong Tam, Travis Walton, Gabriel Birrane, and Jack W. Szostak*, “Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex”, Proceedings of the National Academy of Sciences of the United States of America2017, 114(29), 7659-7664.

14. Wen Zhang, Chun Pong Tam, Jiawei Wang, and Jack W. Szostak*. “Unusual base-pairing interactions in monomer–template complexes”, ACS Central Science2016, 2(12), 916-926. (Featured by ScienceDaily News and Phys News)

13. Wen Zhang, Jack W. Szostak, and Zhen Huang*, “Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom”, Frontiers of Chemical Science and Engineering2016, 10(2), 196-202.

12. Enver C. Izgu, Albert C. Fahrenbach, Na Zhang, Li Li, Wen Zhang, Aaron T. Larsen, J. Craig Blain, and Jack W. Szostak*, “Uncovering the thermodynamics of monomer binding for RNA replication”, Journal of American Chemical Society2015, 137(19), 6373–6382.

11. Liqin Zhang, Zunyi Yang, Kwame Sefah, Kevin M. Bradley, Shuichi Hoshika, Myong-Jung Kim, Hyo-Joong Kim, Guizhi Zhu, Elizabeth Jiménez, Sena Cansiz, I-Ting Teng, Carole Champanhac, Christopher McLendon, Chen Liu, Wen Zhang, Dietlind L. Gerloff, Zhen Huang, Weihong Tan, and Steven A. Benner*, “Evolution of functional six-nucleotide DNA”, Journal of American Chemical Society2015, 137(21), 6734–6737. (Featured by Phys News and Genengnews News)

10. Wen Zhang, Abdalla E. A. Hassan, Zhen Huang*, “Synthesis of novel di-Se-containing thymidine and Se-DNAs for structure and function studies”, Science China Chemistry2013, 56(3), 273-278.

9. Jia Sheng, Wen Zhang, Abdalla E. A. Hassan, Jianhua Gan, Alexei Soares, Song Geng, Yi Ren, Zhen Huang*, "Hydrogen bond formation between the naturally modified nucleobase and phosphate backbone", Nucleic Acids Research2012, 40(16), 8111-8118. 

8. Wen Zhang, Jia Sheng, Abdalla E. A. Hassan and Zhen Huang*, “Synthesis of novel 2’-deoxy-5-(methylselenyl)cytidine and Se-DNAs for structure and function studies”, Chemistry-An Asian Journal2012, 7(3), 476–479. 

7. Wen Zhang and Zhen Huang*, “Synthesis of the 5’-Se-Thymidine phosphoramidite and convenient labeling of oligonucleotides”, Organic Letters, 2011, 13(8), 2000-2003. 

6. Jia Sheng, Abdalla E. A. Hassan, Wen Zhang, Jianfeng Zhou, Bingqian Xu, Alexei S. Soares and Zhen Huang*, “Synthesis, structure and imaging of oligodeoxyribonucleotides with tellurium-nucleobase derivatization”, Nucleic Acids Research2011, 39(9), 3962-3971. 

5. Wen Zhang, Jia Sheng and Zhen Huang*, book chapter: “Structures and functions of nucleic acids modified with Sulfur, selenium and tellurium and complexed with small molecules”, Medicinal Chemistry of Nucleic Acids (John Wiley & Sons, Inc.), 2011, 101-141. 

4. Wen Zhang and Zhen Huang*, “Synthesis of a 2-Selenothymidine phosphoramidite and its incorporation into oligodeoxyribonucleotides”, Current Protocols in Nucleic Acid Chemistry (John Wiley & Sons, Inc.), 2010, 1.23.1-1.23.13. 

3. Abdalla E. A. Hassan, Jia Sheng, Wen Zhang, and Zhen Huang*, “High fidelity of base paring by 2-selenothymidine in DNA”, Journal of American Chemical Society2010, 132(7), 2120–2121.

2. Abdalla E. A. Hassan, Jia Sheng, Jiansheng Jiang, Wen Zhang, and Zhen Huang*, “Synthesis and crystallographic analysis of 5-Se-Thymidine DNAs”, Organic Letters2009, 11(12), 2503-2506. (Featured by C&EN News, vol. 87, no. 23, p. 51, June 8, 2009)

1. Daijuan Wang*,Jin-liang Niu,Wen-bo Zhang,Xiao-juan Jian,Wen Zhang, “Research progress and current status of hemoglobin-based blood substitutes”, Chinese Journal of Biochemical Pharmaceutic, 2005, 26, 379-382. 

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